系列的第二部主要作品，於2011年1月發布並首次加入了網上多人模式。CEC工程師艾薩克成功逃離石村號死靈變體爆發，在宇宙漂流期間被發現並被帶往泰坦空間站。在無法回憶過去三年的情況下，艾薩克在一精神病院內甦醒卻發現病院再次出現死靈變體爆發（前來營救的佛朗哥也被感染成為死靈變體）而被迫獨自逃亡。由於曾於石村號上的秘密貨物神印（The Marker）有所接觸，艾薩克隨即成為政府（希望取得神印的力量和害怕艾薩克會把市內的神印複製體毀滅）和把神印與死靈變體爆發視為神聖之宗教團體統一教（Unitology）的目標，而神印對艾薩克造成的失智症也逐漸加劇。為尋求治療，艾薩克逃避追捕並與市內死靈變體對抗。
絕命異次元2
SKU: 0003
NT$1,590Price
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